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PROGRAM DESCRIPTION
The MPD Foundation seeks proposals for Year 4 of the MPD Research Alliance, a collaborative multi-investigator, multi-year project focused on advancing the understanding of the myeloproliferative disorders (MPDs) and contributing to the rapid discovery and development of effective treatments.
It is the intention of the MPD Foundation to broaden participation in the MPD Research Alliance to facilitate accelerated discovery of effective treatments for the MPDs.
Awards will start at $100,000 per year including up to 8% indirect costs. Awards may be larger based on the quality and potential impact of a proposal; awards are renewable for additional years based on peer review by the Scientific Advisory Board (SAB) of the MPD Foundation and on available funding.
Additional information on the MPD Foundation and on the MPD Research Alliance can be viewed on the Foundation’s website at www.mpdfoundation.org .
KEY DATES
Call for Proposals July 1, 2008
Intent Letter Due September 1, 2008
Full Proposal Due October 15, 2008
Notification of Awards February 1, 2009
Anticipated start of funding April 1, 2009
APPLICATION PROCESS
Applicants for grants for the MPD Rsearch Alliance are requested to submit their applications in two parts:
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Intent Letter. Applicants should email a brief message signifying an intention to submit a full grant application. This message, which is due to the Foundation no later than September 1, 2008, should identify the applicant and his/her contact information and, if possible, should describe the general nature of the work to be done with this funding.
Full Proposal. Applicants should prepare a grant application following the format described below and email this full proposal to the Foundation no later than October 15, 2008.
Printable instructions and application available here
Both Intent Letter and Full Proposal should be emailed to the attention of Michelle Woehrle email address mwhoerle@mpdfoundation.org.
CRITERIA FOR EVALUATION
The following criteria will be used by the Scientific Advisory Board to evaluate proposals for the MPD Research Alliance:
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Support for MPDRA goal. Proposal should make a significant contribution to the Research Alliance’s primary goal, which is to identify, within the shortest time frame possible, candidates for targeted drugs for the Philadelphia chromosome negative myeloproliferative disorders for all MPD patients. Proposal may support this goal through basic or translational research, either building on current JAK2 research or investigating other pathways, as long as the end result of that research will contribute to bringing effective treatments to MPD patients as quickly as possible.
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Innovative approach. Proposal should demonstrate an understanding of current science related to the MPDs, and should build on that science to help provide a direction for future research. An innovative approach which provides such direction to all MPD researchers will be considered an advantage in evaluating the proposal.
Evidence of collaborative potential. The MPD Foundation believes that active and meaningful collaboration among researchers will accelerate the development of treatments for the MPDs. Preference will be given to proposals which demonstrate existing and planned collaboration between the researcher and his/her colleagues, and the potential for collaboration with current MPDRA investigators.
FUNDING LEVEL GUIDELINES
Proposals may request an annual amount up to $200,000, including up to 8% indirect costs. Awards are anticipated to be in the range of $100,000 to $200,000 per year and will be renewable for one or two additional years based on satisfactory progress as determined through review by the MPD Foundation’s Scientific Advisory Board and on available funding.
FULL PROPOSAL FORMAT
Summary Cover Sheet (see attached form)
Proposal Summary (maximum 10 pages single spaced, including any figures and tables)
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Scientific Abstract (200 words or less)
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Lay Abstract (200 words or less)
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Project Description. Must include the following information:
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Specific Aims (please list)
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Previous Work (upon which this project will be based)
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Methods
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Resources and Environment
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Plans for Investigator Collaboration/Interaction
Budget and Budget Justification (see attached form)
Other Research Support (Active and Pending)
Human Investigation Statement (description of any IRB approval/status required for this project)
